http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007105095-A1

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filingDate 2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b450e02f8a93148d6ab9f3e15f5e0489
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publicationDate 2007-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2007105095-A1
titleOfInvention Process for detecting predisposition to a cardiovascular disease
abstract Includes the identification in the genetic material of an isolated biological sample from said human an allelic variant which consist on the substitution of a cytosine by an tymine in the position 46 over the transcriptional origin of Factor XII (46C/T) within the locus of chromosome 5, limited by the D5S400 and D5S408 markers, being the presence of said allelic variant is indicative of a predisposition to a cardiovascular disease. In said process, use is made of a biological sample susceptible of including at least one allelic variant within the chromosome 5 locus limited by the D5S400 and D5S408 markers in order to determine a predisposition to cardiovascular diseases which manifest with thrombotic events. The process permits detection of a predisposition to a cardiovascular disease in a human, so that a suitable preventive an therapeutic strategy can be designed.
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