| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbe98788e47d9b22125cce19367c6e49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec766a1c092439c7ca56ceddc9291ccd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9455a7fbd604d50a0b93255e1cc08450
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c62aa110991260d83cfcfbd8465a7921
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27bfccb2df00fa4c47cce842ae47134e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e82d4e5884ede725e61231addef0888
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c766ecad15cf3af1e341cc575d681a59 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a90c75fc3f2d8bf3b28dbb67d751259
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75cac3a0b980d425dee6b58444e6ac65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a4a136083432a94a5dbc097579e5bab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67390ffca3c857872e79ac40f193372b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2bb837231b16a6740cc254cb6245e8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7a6d4aae366d7f934c83144328a520a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80b9456e6514e31391e74411c598bc06 |
| publicationDate |
2007-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007100559-A1 |
| titleOfInvention |
Crystal structure of a deacetylase and inhibitors thereof |
| abstract |
The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007087427-A1 |
| priorityDate |
1999-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |