abstract |
A pharmaceutical composition in the form of a solution, cream, lotion, spray, ointment, gel, aerosol, tablet, suppository or patch device for transdermal or transmucosal administration of alprazolam to a subject, which includes as a permeation enhancing mixture a fatty component in an amount of 0.1% to 20% by weight which is one of (a) a saturated fatty alcohol of formula CH 3 —(CH 2 )n—CH 2 OH, a saturated fatty acid of formula CH 3 —(CH 2 )n—CH 2 COOH, (b) an unsaturated fatty alcohol of formula CH 3 (C n H 2(n−1) )—OH, or (c) a fatty acid of formula CH 3 (C n H 2(n−l) )—COOH, wherein n is an integer of between 8 and 22; and a vehicle that includes a C 1 -C 4 alkanol, a polyalcohol, and water. |