| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bda4a06328bbe393b548c07db0d6aab |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6903
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2005-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98a8267ab7028ba91749091832739cac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_babb6325a0940c632a1612028fdc4246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_035362225dbbbb7b5a45ecc217157458 |
| publicationDate |
2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007092508-A1 |
| titleOfInvention |
Detoxification depot for Alzheimer's disease |
| abstract |
The invention is directed to a device that is placed inside an Alzheimer's disease (AD) patient for the purpose of extracting and accumulating neurotoxic beta-amyloid peptides (nt-bAP) from body fluids. AD is the consequence of a process in which nt-bAP aggregates to form fibrils and plaques which can cause nerve damage. Since nt-bAP can cross the blood-brain barrier (BBB), the concentration in the central nervous system and in the periphery are in equilibrium. By sequestering nt-bAP, our device will act as a “sink.” It should draw nt-bAP across the BBB, reducing the concentration of soluble nt-bAP in the brain, thereby halting or slowing plaque deposition in the brain. Since plaques and possibly soluble, aggregated nt-bAP are the cause of nerve damage in AD, this process should be therapeutically effective. The device can be a depot containing a fragment of nt-bAP which intrinsically retains the ability to bind but not to be toxic. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9591845-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10167318-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9464118-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010158893-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10123530-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015515491-A |
| priorityDate |
2005-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |