| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84ba8ad05866aa606a7e6b2d6abe83b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10ec4f2fa2df363f773dc8d64754a310
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_613e824dcd03ff38288251755e08c6c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1e1dc400b975e1a19d1ec5fc0d39963 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2003-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7968abd4af2e43a2c370b7bf83f858b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62a89eb0adff39eae05241fd605c9fab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237bb665329a0117e3f546714d7c412d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb137fe11b278358b6157361b9da2567 |
| publicationDate |
2007-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007059792-A1 |
| titleOfInvention |
Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation |
| abstract |
The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022143532-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009032181-A3 |
| priorityDate |
2002-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |