| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e24599c467445e4dcd5ebd11cef4308e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04960a69e159a5dee12959bcfe55548a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f961d237a3c4896f5c0100cdd5a516
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce85e27a14c9fd41bc95336fe28310cd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-849 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0075 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-727 |
| filingDate |
2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efcc7a5c74306f7e7a724b9fe08bc399
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66e74ab8b4b53f25b4bb1ba802d841df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3fe45fccc141c4e930918c6b5357d78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2baa96daaad91e3380eea86f3c08545 |
| publicationDate |
2007-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007042993-A1 |
| titleOfInvention |
Polysaccharides derivatives with high antithrombotic activity in plasma |
| abstract |
The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N-acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli , b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-0-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both 0-sulphations (0-sulphation and 60-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-Ila activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9012168-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10704068-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013116677-A3 |
| priorityDate |
2003-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |