abstract |
This invention relates to a process of stereoselectively synthesizing an alcohol of the following formula: n n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined in the specification. The process includes reacting (R) 4-formyl-2,2-dimethyldioxolane with α-bromoacetate in the presence of Zn and a Zn activating agent. |