| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cd23dc36c6051a7715d8265066b9474 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2517-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-02 |
| filingDate |
2006-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e82011da79d868a06dc1fe4f773d80c |
| publicationDate |
2007-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007010897-A1 |
| titleOfInvention |
Immunochemically modified and sterilized xenografts and allografts |
| abstract |
The invention provides an article of manufacture comprising a substantially non-immunogenic xenograft for implantation into humans. The xenograft is a body part dissected from a transgenic 1,3-α-galactosyltransferase gene-deficient animal, wherein the cells of the body part are dead. The invention also provides methods for preparing a xenograft by removing a body part from a transgenic animal, which is 1,3-α-galactosyltransferase gene-deficient, to provide a xenograft; optionally washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; optionally treating the xenograft with crosslinking agents, and optionally treating the xenograft with a proteoglycan-depleting factor. The invention further provides a method for sterilizing xenograft material, having the steps of obtaining substantially non-immunogenic xenograft material; treating the xenograft material with at least one crosslinking agent; and subjecting the crosslinked xenograft material to a radiation treatment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9956316-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957477-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10940184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11724004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11052175-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307510-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8753406-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011156704-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10207025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10413634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8736265-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10814033-B2 |
| priorityDate |
2005-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |