| abstract |
The present invention is directed to labeled compounds of the formula Ar-Z 1 -Q-Z 2 where Ar is an aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure n n nwherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of hydrogen, a C 1 -C 4 lower alkyl, a halogen, a phenyl, an alkoxy group and an amino group from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each a C 1 -C 4 lower alkyl, Q is selected from the group consisting of 13 CH 2 , 13 CDH and 13 CD 2 , and Z 1 is selected from the group consisting of —S—, —S(═O)—, —S(═O) 2 —, —Se—, —Se(═O)—, and —Se(═O) 2 —, Z 2 is selected from the group consisting of —Si(R 6 R 7 R 8 ), —O(R 9 ), —Se—Ar, —Se(═O)—Ar, —Se(═O) 2 —Ar, —S—Ar, —S(═O)—Ar, and —S(═O) 2 —Ar wherein R 6 , R 7 and R 8 are each independently selected from the group consisting of a C 1 -C 4 lower alkyl, R 9 is a C 1 -C 4 lower alkyl or an R 10 —Ar group where R 10 is a C 1 -C 4 alkylene group. |