| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0eff632cf7b2763e23e5e35cc71ca8f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c4f2676a67fae193c4f5a2c9d50c303
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6d9ad987db8d5e9e04d428801c605d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e19f28f993d24adcd12ea16ef674b1d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-757
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7779
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-111666 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01B11-2441
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-4788
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-45 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-00 |
| filingDate |
2006-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a878cd489502b660916e8fc36c6f78f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3045c6f1efd6964b0f942eb0d6d440bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_660d4beef2bd4f566085587be47cecf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec3a38cd0a9ba8a924a94cea8b06f9b0 |
| publicationDate |
2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007003436-A1 |
| titleOfInvention |
Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay |
| abstract |
A phase contrast quadrature interferometric method for determining the presence or absence of a target analyte in a sample. The method comprises using a laser beam having a wavelength λ and a waist w o to probe at least a portion of a substrate having a reflecting surface that has been exposed to the sample. The reflecting surface includes at least a first region having a layer of recognition molecules specific to the target analyte and a second region that does not include a layer of recognition molecules specific to the target analyte. The method further comprises measuring a time dependent intensity on a photodetector of a substantially only first quadrature at one of a pair of quadrature angles ⊖ q of a reflected diffraction signal of the probe beam while probing the first region and the second region. An apparatus for phase-contrast quadrature interferometric detection of the presence or absence of a target molecule on a planar array, comprises a laser source for generating a probe beam. The apparatus includes a platform for receiving the planar array and a first optical train for directing the probe beam at the platform in a substantially surface normal manner. The apparatus also includes an objective lens having a first side and a second side and having a focal length, the objective lens being offset on the first side of the lens from the platform by a first distance approximately equal to the focal length. The apparatus further includes split photodetector means for measuring a first quadrature and a second quadrature in a signal resulting from reflection of the probe laser beam. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008089495-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7910356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8298831-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008230605-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009263913-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008089495-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10613096-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008175755-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7659968-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7663092-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006256350-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006256676-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008144899-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018081646-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008129981-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8072585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10060850-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7405831-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7787126-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11187584-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018080870-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008118934-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016161337-A1 |
| priorityDate |
2005-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |