Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47f079fed01315e7f0429c70e359a9b7 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-00 |
filingDate |
2006-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6350324b40041ca970ce355e4e5f1aea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b7417d03d7fef1861532645f3a854ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec2004594dff4871aa0d2030b8b284de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbba7cd787e607926d09cd18f51de598 |
publicationDate |
2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2006293530-A1 |
titleOfInvention |
Process for the manufacture of citalopram hydrobromide |
abstract |
The present invention describes an improved process for the preparation of pure 1-(4′-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-phthalanecarbonitrile and its bromide salt (citalopram hydrobromide), which is a well known antidepressant. Another aspect of the invention is isolation of crystalline (4-Bromo-2-hydroxymethyl)phenyl-(4-fluorophenyl)-3-(dimethylaminopropyl)methanol (Bromodiol) and conversion of desmethylcitalopram which is formed during the cyanide exchange reaction, to citalopram by heating with a mixture of formaldehyde and formic acid in chloroform. The resulting citalopram is purified using conventionally extraction methodology. |
priorityDate |
2003-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |