| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25b38b92327582833c159cda3613c973
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_771d3b577cd0b6eff42dc3cb7f21db83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e12c448df21736b7c359bb31bdd4c23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_296690651d2249619a95574549803a74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1641 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate |
2005-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2146e7cb3c30b675af6a5a0baeae8036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e845093474e7d0d77777d69a8955bda1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1c2f045753f2552530645e18ccdf873
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdf8d73a17c8d12ee11ea3b835a544e6 |
| publicationDate |
2006-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006286165-A1 |
| titleOfInvention |
Taste-masked pharmaceutical particle, the preparation and use thereof |
| abstract |
The present invention provides a taste-masked pharmaceutical particle prepared by a polymer blending process, a process for preparing the particle, and the use of the particle in preparing the orally disintegrating tablets. In this process, a micronized active drug ingredient is mixed with three kinds of pharmaceutically acceptable polymer adjuvants to yield a complete and uniformly mixed sheet with smooth surface and good plasticity. The sheet is knocked into small blocks, and then pulverized and pelleted to yield a taste-masked pharmaceutical particle whose bitter or peculiar taste is not felt in 120 s. The taste-masked particle can release the drug in a very high speed in an acidic solution (pH=1.0) and release the drug in a high speed in a solution with low acidity (pH=4.0), and effectively disperse in a solution with very low acidity (pH=6.8). The taste-masked particle can be directly tabulated after mixing with appropriate adjuvant to yield an orally disintegrating tablet with a uniform content, low friability, and ability to disintegrate in about 45 s. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013156871-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104887634-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008031944-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013065068-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10835495-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019336476-A1 |
| priorityDate |
2005-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |