http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006281687-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e0cebf9bcc59d631f64a0a155811c99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_feae74f9f19f8e635d08612256d5b444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e66d638fdbd2d3656610913c1ed01d19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8191efcbfaaa404959f70ca46cc30ce |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4739 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2006-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c257ed932f634231111988c8975de569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df8b369b14804592fc63b877ff9e5df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5d5ae518b6a6f391aaf49047e01c6fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d88d2fb6dc85b42b283f6c48748ee27c |
| publicationDate | 2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006281687-A1 |
| titleOfInvention | Cyclin groove inhibitors |
| abstract | The present invention relates to a compound of formula I, or a variant thereof,n nA-(B) m -C-(D) n -E (I)nwherein m and n are each independently 0 or 1 and A, B, C, D and E are each independently linked to the respective adjacent residue by a linker group independently selected from carboxamide, reduced carboxamide, sulfonamide, imine, semicarbazone, oxime and ethanolamine; n A is (i) a natural or unnatural amino acid residue having a side chain comprising at least one H-bond acceptor moiety and at least one H-bond donor moiety, or a derivative thereof; or (ii) R(CO), wherein R is a C 1 -C 24 hydrocarbyl group comprising at least one H-bond acceptor moiety and optionally one or more H-bond donor moieties, and where R optionally contains one or more heteroatoms selected from S, O, and N, and is optionally substituted by one or more substituents selected from halogen, OMe, CN, CF 3 , and NO 2 ; each of B and D is independently an amino acid residue selected from arginine, 4-(guanidinyl)phenylalanine (4-(Gu)Phe), piperidinylglycine (PipGly), piperidinylalanine (PipAla), pyridinylalanine, histamine, N,N-(dimethyl) lysine (DMLys), citrulline, glutamine, serine, lysine, asparagine, isoleucine and alanine, or a derivative thereof; C is NH—X—CO, where X is a C 1 -C 4 alkylene group substituted by a straight-chain or branched C 1 -C 6 alkylene group, said C 1 -C 6 alkylene group optionally containing a H-bond donor or H-bond acceptor moiety; E is (i) a natural or unnatural amino acid residue having an aryl or heteroaryl side chain, or a derivative thereof; or (ii) NHR′, where R′ is a C 1 -C 24 hydrocarbyl group, optionally containing one or more heteroatoms selected from N, O, and S, and optionally comprising one or more H-bond acceptor or donor moieties; said hydrocarbyl group further comprising a pendent C 4 -C 12 aryl or heteroaryl group, which itself may be optionally substituted by one or more substituents selected from a H-bond donor moiety, a H-bond acceptor moiety, a halogen, Me, Et, i Pr, CF 3 , CN and NO 2 ; wherein at least one of A and E is other than a natural or unnatural amino acid residue when A, B, C, D and E are each linked to the respective adjacent residue by a carboxamide group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9376465-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015011730-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014296484-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858606-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004087560-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982015-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162083-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11597737-B2 |
| priorityDate | 2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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