| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52188ee79ecd3d89f92538f8d847d62f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ff2c7b81833ad9f2f6ba57970978fe5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8f2ed60e5533cd55770d2b4e4c1707d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49cb470d7fb77a7de945fa81fd2ed0da |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-105831 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2006-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c3b92ca78f7d6795307c53ac5a29f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8b7a95bd40aa300a9a63f09652a634d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53b10d1c8958807a6194b37c8f23b5d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e3f651eb1034bbb02ccd5081a6c6db6 |
| publicationDate |
2006-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006234385-A1 |
| titleOfInvention |
Polyglutamine repeat sequences |
| abstract |
Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing polypeptides containing a polyglutamine repeat sequence, for storing these polyglutamine polypeptides and inhibit their spontaneous aggregation, for making the aggregates of polyglutamine polypeptides, for assaying the extension of existing polyglutamine aggregates, for determining the ability of a chemical compound to inhibit aggregation, and for inhibiting aggregation of polyglutamine polypeptides. The invention further provides materials with which to study these diseases including a synthetic aggregate that have a capability to recruit additional monomeric polyglutamine polypeptides and chemical compounds that inhibit the formation and/or extension of polyglutamine aggregates. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016120247-A1 |
| priorityDate |
2002-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |