| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a947c5b565bf9b9919794f03db37eca |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 |
| filingDate |
2006-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf09914839a893dbd15acfb5837f4fbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063ae1112a20c146395d817762b396c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b802e43779617abe0c364f20e909da5 |
| publicationDate |
2006-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006223999-A1 |
| titleOfInvention |
Process for preparing montelukast and precursors thereof |
| abstract |
The present invention provides a process for stereoselectively reducing 2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-oxopropyyl]benzoic-acid methyl ester, to produce to produce methyl 2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]benzoate, and a process for producing montelukast or a salt thereof. The present invention further provides a process for purifying methyl 2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]benzoate. The reduction process of the present invention uses a chiral reagent and can produce the desired reduction product in high enantiomeric excess (ee). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010076195-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014081616-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7812168-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102574803-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007078158-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011042416-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008131932-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009270628-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8617853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088610-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1988079-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009155863-A1 |
| priorityDate |
2006-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |