| abstract |
This invention relates to a process for preparing a 3′-deoxypentopyranosyl oligomer, which includes the steps of bonding a 4′-protected-3′-deoxypentopyranosyl nucleoside to a solid support, deprotecting the nucleoside at the 4′-position, reacting the 2′OH group with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product. The steps of deprotecting the nucleoside at the 4′position, reacting the 2′OH group with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product can be repeated one or more times to produce the desired length of oligomer. |