| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d22b649c54d79d7c1eabf23085b14a3e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-104
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 |
| filingDate |
2006-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06b5df78ce9b7f33aeb00d6d21051fff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7dad97daa620b0fd2748233c3df39a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52133bd0a77bc0d308ebf6234c34e8b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a0057ab81cdc70d3c10b01aed74bd5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96505bcdb0465214a8ec2723dde60d58 |
| publicationDate |
2006-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006204520-A1 |
| titleOfInvention |
Vaccine composition |
| abstract |
The present invention relates to the field of novel, engineered Gram-negative bacterial strains that have improved outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperblebbing Gram-negative bacterium which has been genetically modified by either or both processes selected from a group consisting of: down-regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9687789-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007087017-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010247566-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642046-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008085055-A1 |
| priorityDate |
2001-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |