| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f39ee1e317e46e488912539bd7ff0f7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc77e2731ae5bfebdfad5bc4d49565ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba9cc62c897830ab9072b0d6d44c151b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e75628cc022dae9684d38872e6f0065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9bff03da6dd1428649496f13c441cdf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2003-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6507834231c8e145367ca18e3c2c485e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2675847be108856a9d729af357a2107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8eff5073374c3c95c571960e9f631f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdf64d014bf6a7640745ecc63cc8fade
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a33d655289ceaaef4be4f4944eb395 |
| publicationDate |
2006-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006204496-A1 |
| titleOfInvention |
Agonist antibody against heteroreceptor |
| abstract |
Animals were immunized with either the A or B chain of a receptor, and then mRNA was extracted from the spleen cells of the animals, and the variable regions of the L and H chains were isolated by RT-PCR using primers for variable regions comprising CDRs. Single-chain Fv was synthesized by assembly PCR to construct a phage library. Clones for antigen-bound antibodies were concentrated and cloned by panning. An expression vector for scFv-CH1-Fc was prepared by inserting a single-chain variable region between CH1-hinge-CH2-CH3 and the signal sequence for animal cells. Various combinations of such expression vectors were introduced into cells to express antibodies, and antibody clones exhibiting ligand-like activity were selected. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9708407-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10494432-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10398765-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11000510-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11760810-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE48558-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10981987-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102459628-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10544218-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018032574-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8617554-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010132659-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10995152-B2 |
| priorityDate |
2003-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |