http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006188474-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6475 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 |
| filingDate | 2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ed4c7615e34a2e2d56a5e9032cf9725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e11aae5ebdb15ef13576830ed50bc64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_000ade3e59e68f83daa3ea2d6daaa3bc |
| publicationDate | 2006-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006188474-A1 |
| titleOfInvention | Interleukin 1beta protease and interleukin 1beta protease inhibitors |
| abstract | There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: n nR 1 -Asp-R 2 -R 3 n nwherein R 1 and R 3 are independently any D or L isomer amino acid, R 2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R 2 . Inhibitor compounds, compositions and methods for inhibiting Interleukin 1β protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006128696-A1 |
| priorityDate | 1990-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 399.