| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_036f75f3352c2420f938f3b23b4d6475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19c7b0b3ae25cc8fffd997da80cfd7f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf64a6f2740cafb90dbcf5ebf3dfe21e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acb2036f3b1e2e4abfc9a33a5b716f20 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-0201
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y205-01019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y501-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-01002 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2002-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_688cfdbae6d3c7bd8ba9dbee990908e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f7088ad9c82159383ea09b39b9a6730
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dabba18eea3a36c288f1c5e517992fa7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_defc38faf2f9284cb3eb4648f834ac54 |
| publicationDate |
2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006183676-A1 |
| titleOfInvention |
Treatment of mycobacterium tuberculosis with antisense oligonucleotides |
| abstract |
Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA transcript expressed by Mycobacterium tuberculosis are provided. Typical methods of the invention utilize phosphorothioate modified antisense polynucleotides (PS-ODNs) against the mRNA of M. tuberculosis genes such as glutamine synthetase, aroA, ask, groES, and the genes of the Antigen 85 complex. Optionally, the methods employ multiple antisense polynucleotides targeting different Mycobacterium tuberculosis transcripts. In preferred embodiments of the invention, the antisense polynucleotides are complementary to the 5′ regions of the Mycobacterium tuberculosis transcripts. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109234414-A |
| priorityDate |
2001-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |