| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30c2c819835b507b2baab913ca003d48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d8b3e5663a841e8a71b6b31a160ff9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e46a1c727155b4b8b2b25b178c48a63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fe44f331156da56138ddf2a903306aa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2004-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b93aa9b6f4c7b1eeafda75787cd789b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_928354cd6af003729c177ce48895b6a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_493370720cf8feaa6d8ef22591677a72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76162334eb9a1b4cb46d7ec6feb3049c |
| publicationDate |
2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006172958-A1 |
| titleOfInvention |
Phospholipid scramblase 3 |
| abstract |
Phospholipid scramblase 3 (PLS3) is a newly recognized member of a family of proteins responsible for phospholipid translocation between two lipid compartments. A novel isoform of PLS3 is identified and characterized herein. The function of PLS3 in mitochondria was disrupted, yielding an inactive mutant PLS3(F258V). Cells transfected with PLS3(F258V) exhibited reduced proliferative capacity that was unaffected by the presence of Na 3 N. PLS3(F258V)-expressing cells exhibit abnormal mitochondrial metabolism and structure and were associated with decreased sensitivity to UV- and tBid-induced apoptosis, and diminished translocation of cardiolipin to the outer mitochondrial membrane. Cells transfected with wild-type PLS3 displayed increased sensitivity to apoptosis and enhanced cardiolipin translocation. These studies identify PLS3 as a regulator of mitochondrial structure and respiration, and cardiolipin transport in apoptosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9857357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2921854-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014077279-A1 |
| priorityDate |
2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |