| abstract |
The invention relates to novel peptides which are biologically active as ligands of blood platelet integrin GPIIbIIIa and the α v integrins, preferably the αvβs and α v β 3 integrin, having the formula (I): R 1 -Arg-X-Asp-Leu-Asp-Ser-Leu-Arg-R 2 (I), in which R 1 denotes H, acetyl or acyl and R 2 denotes -Oh, OR 3 NH 2 ,NHR 3 , N(R 3 ) 2 R 3 denotes atkyl, aralkyl, aryl, Het and X denotes an amino acid of the formula (II), in which A denotes (CH 2 ) n R 4 denotes H, alkyl, aralkyl or aryl, and n denotes 1, 2, 3, 4, 5 or 6, and the amino acid of the formula (II) is bonded to the adjacent Arg via a peptide bond of the α-amino group and to the α-amino group of the adjacent Asp via a peptide bond of the α-carboxyl group. |