http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006134642-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2004-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb5c409820992928ec5e0a4b7de760ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87146fbe3c1cc4bd970ce16f1569fcb1 |
| publicationDate | 2006-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006134642-A1 |
| titleOfInvention | Pharmacological targeting of bacterial DNA ligase for treatment and prevention of bacterial infections |
| abstract | This invention provides methods for the discovery of molecules that target an essential step of bacterial DNA replication—the sealing of DNA strands by NAD + -dependent DNA ligase. Specific structural components of NAD + -dependent DNA ligase that are important for the reaction of DNA ligase with NAD + and that comprise a putative binding site for the NMN component of NAD + were identified. The invention also includes recombinant DNA ligase enzymes that are defective in their reaction with NAD + , but active in the ligation of pre-adenylated DNA nicks. An underlying principle of this invention is the use of NAD + -reactive and NAD + -defective ligases to identify molecules that specifically bind to the NAD + -binding site of DNA ligase and thereby interfere with the reaction of DNA ligase with NAD + . |
| priorityDate | 2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 180.