| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94a7694fb1a6c4a5d2bfe7f698014612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba2f20293b4e9190fda657705115dc17 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65744
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-576
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 |
| filingDate |
2004-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45dabf3995baf5e86aa6a95070380e1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac9ab2b53040c5b32ebc683d56dec03f |
| publicationDate |
2006-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006128668-A1 |
| titleOfInvention |
Pancratistatin cyclic phosphate prodrugs an phenpanstatin cyclic phosphate prodrugs |
| abstract |
Selective phosphorylation of phenpanstatin ( 3 a ) with tetrabutylammonium dihydrogen phosphate and dicyclohexyl-carbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient route to a new series ( 3 b - 3 d ) of promising 3,4-O-cyclic phosphate prodrugs designated phenpanstatin phosphates. Application of analogous reaction conditions to pancratistatin ( 1 a ) led to a mixture of monophosphate derivatives where sodium paancratistatin 4-O-phosphate ( 4 a ) was isolated and the structure confirmed by x-ray craxtallography. Modification of the reaction conditions allowed direct phosphorylation of pancratistatin followed by cation exchange chromatography to afford sodium pancratistatin 3,4-O-cyclic phosphate ( 5 b ) which was selected for preclinical development. |
| priorityDate |
2003-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |