| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e44333393916a1ef9c9f10566af4833d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-17003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y403-02005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 |
| filingDate |
2005-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bce90d61c723e7b46d31444bf6ac178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4142e76bbd06faa7ff711425fa90d77a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0a685b33b09217a2b3d6454b295075b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2d53afea22fe8f14416cd4d2fddd52e |
| publicationDate |
2006-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006127995-A1 |
| titleOfInvention |
Enzymatic reactions in the presence of keto acids |
| abstract |
Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X—NH 2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished enzymatically in the presence of keto acids, or salts or esters thereof, to provide a good yield without the necessity of catalase or similar enzymatic reaction enhancers. Peptidylglycine α-amidating monooxygenase (PAM) is a preferred enzyme for catalyzing the conversion. Alternatively, peptidylglycine α-hydroxylating monooxygenase (PHM) is utilized to convert X-Gly to X-alpha-hydroxy-Gly which may be recovered, or optionally may be simultaneously or sequentially converted to an amide by either a Lewis base or action of the enzyme peptidyl α-hydroxyglycine α-amidating lyase (PAL). Both PHM and PAL are functional domains of PAM. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8377863-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394342-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3009129-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010311650-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9399017-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9833411-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8076291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8592366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010085700-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006172-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8513183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009317462-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8378067-B2 |
| priorityDate |
2004-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |