| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbb7c566de48ddc2f6ab493710ddc328 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 |
| filingDate |
2006-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df41c9c43fb0067ddd65ef433f1e170a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26a2040dc1fb55d7d36c86443b9b5647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe7e7698fb102e05c1b47532ab37ae08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27f1ac506386240df4b11c789526952e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a58da8a1f1abcb9ec47ae9328e09980 |
| publicationDate |
2006-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006127471-A1 |
| titleOfInvention |
Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy |
| abstract |
Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. At least one of the phospholipids in the liposomes has been linked with poly ethylene glycol (PEG) as an integral part of the phospholipids. The formed pegylated liposomes contain the hydrophobic photosensitizer within the lipid bilayer membrane. Pegylation of liposomes carrying the hydrophobic photosensitizer helps to maintain the drug level within the therapeutic window for longer time periods and provides the drug a longer circulating half life in vivo. Further the pegylated formulation of hydrophobic photosensitizers shows improved pharmacokinetics over standard non-liposomal formulations thus enhancing the efficacy of PDT with the pegylated liposomal formulations. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2222277-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008088810-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009065065-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2222277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017148454-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777760-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008088810-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009067203-A1 |
| priorityDate |
2003-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |