| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2647781193636ae95d1f745755a9a7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84bbe92ce8563d6d89fb383905d4e13a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate |
2004-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd23008ab63450062677039559cf0c5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8be68cfa8e86c2f158381f2bc0b763d3 |
| publicationDate |
2006-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006111369-A1 |
| titleOfInvention |
Synthesis, characterization and biological action of optically active isomers of floxacins |
| abstract |
Disclosed herein is the method for synthesis and separation of enantiospecific isomers of floxacins. These isomers can be used to study the antibacterial action, as well as cardiac effects, such as arrhythmogenic activity, QT internal prolongation and dispersion, and Ikr inhibition in humans. A method for the identification of chiral isolates of the floxacins that are devoid or possess less QT prolonging action and thus cause less arthropathy especially of the Torsades de pointes variety. Also disclosed are methods for assaying these isomeric compounds present in the biological fluids. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2597976-R1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109632921-A |
| priorityDate |
2004-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |