| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d0767d018326adc9aacc142c0c6c2a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82f976b42e85a823e46f420dd8d7d527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9465f0a6939d9a6c4ab97fd3f6338964 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5735
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 |
| filingDate |
2005-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77304859a75aeb9e5fb1246d23e9991a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d31391c14f7777ee683708ed56a1f5d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0f3ef629a58baeb25c62f283ed71476 |
| publicationDate |
2006-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006110814-A1 |
| titleOfInvention |
Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use |
| abstract |
Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and γ-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010022625-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323009-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021366-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11186555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3050593-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8785483-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-030611-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9308206-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014145314-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016515531-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-FI20120053-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014206693-A1 |
| priorityDate |
2004-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |