Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73dac0dfbd378b17ab068cdba2943b25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_137a5c4278bcf5e3a1c47070df157028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b649fc71800473acc4b826a95a9e7bd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc84d7c36ddd4ed296da470091a25228 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03d7aa898bde98aedf7faff9e6286564 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
filingDate |
2003-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e32d00de0d04fb34d3591bbd6102bd0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ebb363f62c828ea62712105ff670285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_547e9f41a04d00ef45d7e3808389db04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_919c18c77544d86cf79e81f5a3c6bd21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1bb8bea1022d84dcabf2b34b828002b |
publicationDate |
2006-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2006110789-A1 |
titleOfInvention |
Methods to mediate polyketide synthase module effectiveness |
abstract |
Linking sequence which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides. The modules are provided suitable linkers so that the polyketide chain is passed from one module to the other in the correct sequence. Synthetic peptides which mimic linkers can be used to inhibit the synthesis of polyketides. Kinetic channeling, both intrapolypeptide and interpolypeptide, of diketide intermediates in a Type I polyketide synthase can occur. In addition, the role of protein-protein interactions between a donor acryl carrier protein (ACP) domain and a downstream ketosynthase (KS) domain and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules and between a polyketide synthase module and a NRPS module has been identified. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011008829-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2255005-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2255005-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9856460-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8765403-B2 |
priorityDate |
2002-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |