| abstract |
The invention provides isolated nucleic acids molecules, designated MKP nucleic acid molecules, which encode novel MAP kinase phosphatase family members, and their use in metabolic disorders. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MKP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MKP gene has been introduced or disrupted. The invention still further provides isolated MKP proteins, fusion proteins, antigenic peptides and anti-MKP antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided. |