| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30546cfe9e8e8c70d18557f16450601b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 |
| filingDate |
2004-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21daeb02d9f24d21ccab9d669a1d4cab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80b0799a804269dca0aea47dd67e9d75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9211f859e4a1a6647eb7357f6cef2b55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a30e62dc38eaa9b97f33babe16adc47 |
| publicationDate |
2006-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006106098-A1 |
| titleOfInvention |
Andrographolide and its derivatives as TNF-alpha antagonists |
| abstract |
The present invention relates to andrographolide and its derivatives of the general formula (I), as well as the stereoisomers and salts of andrographolide and the derivatives. n n nAndrographolide and its derivatives represented by general formula (I) defined above are useful as TNFα (tumor necrosis factor alpha) antagonists or inhibitors which have inhibitory effect on the binding of TNFα to TNF-RI. Andrographolide exhibited inhibitor activity with IC 50 values 60 μM on L929 cell proliferation/cytotoxicity assay without cell cytotoxicity. In addition, in the animal model test of collagen-induced arthritis, andrographolide exhibited 50% paw edema. Andrographolide and its derivatives are promising sources with high TNFα-inhibiting or antagonizing activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103739597-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107973764-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104352427-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103739597-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106432153-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109942520-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111728967-A |
| priorityDate |
2004-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |