| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f85681162022797de52846bd2fc56827 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 |
| filingDate |
2005-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df9414bc6eab89de8a659edefa000fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de3227df22d0ac5a176f1887ee451d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a6f9584b384af532ab9c1fc9aad3a48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07f863052d6e5fe2663ef3f26881936c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2a92119a4402a4bad395ca8ad29af11 |
| publicationDate |
2006-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006094059-A1 |
| titleOfInvention |
Methods for identifying new drug leads and new therapeutic uses for known drugs |
| abstract |
The screening system utilizes dynamic measurements of pathway activity to detect the activities of drugs within cellular pathways. The methods of the invention can be used to identify previously unknown drug activities and therapeutic uses, even for drugs that have been well characterized with standard biochemical assays. We demonstrated the utility of the invention by screening a portion of the known pharmacopeia. We identified dozens of drugs, previously or currently marked for a variety of indications, with surprising and previously-unsuspected activity against ‘hallmark’ cancer pathways. We also showed that over 20 of these drugs indeed have anti-proliferative activity in human tumor cells, underscoring the utility and predictability of the screening system. The methodology will extend the utility of the current pharmacopeia and provide the basis for de novo discovery of drugs with a broad range of therapeutic indications. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9310353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009062135-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10718755-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249231-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102286488-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010081632-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865901-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9107907-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008280777-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010010797-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011041731-A3 |
| priorityDate |
2004-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |