http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006058343-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e270fe16806cd03bc5ef00f7d0069db http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdde0a7fb929c42f94331472b538cd9a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-06 |
| filingDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b957f7ad23d335071d7caf8c5925b7b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8972d5001a575fff577f7bda4b757409 |
| publicationDate | 2006-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006058343-A1 |
| titleOfInvention | Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols |
| abstract | The present invention relates to a process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols having the structural formula I n n nor a pharmaceutically acceptable salt or solvate thereof, wherein R is benzyl, R 5 -benzyl, allyl, —C(O)R 6 , —C(O)OR 8 or —CH(R 7 ) 2 ; n R 1 is optionally substituted aryl or optionally substituted heteroaryl; and R 5 , R 6 , R 7 and R 8 are as defined in the specification; comprising a) reacting an amine of formula II n nR—NH 2 II n nwith 2,5-dimethoxytetrahydrofuran or HC(O)(CH 2 ) 2 C(O)H, and C(O)(CH 2 C(O)OR 4 ) 2 , wherein R 4 is H or alkyl, to obtain a compound of formula III n n b) reacting a compound of formula III with I-R 1 , alkyl lithium, and optionally a lithium salt, to obtain a compound of formula I; and c) optionally converting a compound of formula I wherein R is benzyl, R 5 -benzyl, allyl, —C(O)R 6 or —C(O)OR 6 to a compound of formula I wherein R is —CH(R 7 ) 2 . Intermediates in the process are also claimed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007191355-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7671198-B2 |
| priorityDate | 2004-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 267.