| abstract |
The invention relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate cell activation or migration, e.g., lymphocyte migration, via modulation of the expression and/or activity of migration molecules such as, for example, EDG molecules (e.g., EDG1 and EDG3), selectins, integrins, cadherins, certain members of the immunoglobulin superfamily of molecules, or chemokine receptor molecule. The methods of the invention are efficient and readily amenable to high-throughput drug screening protocols. High-throughput screening (HTS) methods, compositions, and kits for performing the assays are also provided. |