Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_899571595cdfdef71590e78c23368a82 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00932 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F2025-913 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-0086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00788 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F33-30 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F5-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
filingDate |
2003-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4aba3a810db4542ee3e128cb8ba9d4 |
publicationDate |
2006-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2006052583-A1 |
titleOfInvention |
Protein production |
abstract |
Proteins may be made by genetically engineered microorganisms, the protein being stored in the form of inclusion bodies (IB). The proteins in the inclusion bodies are in an insoluble and inactive form. They may be dissolved using a solubilisation reagent ( 18 ), and the resulting solution diluted so that the proteins refold into the active form. This refolding of the protein is enhanced by subjecting a solution or suspension of the protein to low intensity sound waves ( 25 ), at a low enough intensity that the protein is not denatured. The intensity may be between 10 and 100 mW/cm 2 . |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8586890-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007111535-A1 |
priorityDate |
2002-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |