| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46f442bf71ad881826c4e3cb979ac1b8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 |
| filingDate |
2005-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d36fa5f0f24782cb76c9fbeaf38009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_121e2c9bfebdb70ef7dca93330e6fd66 |
| publicationDate |
2006-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006030578-A1 |
| titleOfInvention |
Pharmaceutically active lipid based formulation of irinotecan |
| abstract |
Delivering therapeutic amounts of irinotecan remains limited due to its highly water insoluble properties. This invention overcomes this limitation by presenting a novel method of preparing liposomal irinotecan by first inactivating irinotecan prior to liposome formation and then subsequently activating the irinotecan by lowering the pH of the lipid composition to an acidic pH of less than about 3.5, such as between 1.5-3.0 or about 2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878054-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11090299-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315828-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113993507-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017003120-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005191343-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8338584-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008242691-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010305190-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010063131-A1 |
| priorityDate |
2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |