| abstract |
(wherein R 1 , R 2 and R 3 may be the same or different and each represents a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; and R 4 represents cycloalkyl, —(CH 2 ) n —R 5 or the above formula (II)) nThe present invention provides a solid formulation comprising a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, which possesses excellent pharmaceutical properties, for example, in hardness, disintegration property, dissolution property, stability or the like. |