| abstract |
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, n n nin which E is n n nX is N or CH, W is —NR 16 R 17 , —NR 16 C(═O)R 22 , —NR 16 CO 2 R 22 , —OR 23 , or a heteroaryl or heterocyclo group as defined in the specification, and R 1 through R 12 , R 16 , R 17 , R 22 , R 23 , x, y, and z are as defined in the specification, are useful as modulaters of melanocortin receptors, particularly MC-1R and MC-4R. |