| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e28c39e4d647aa7d2ef6e37ee5a5f4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138 |
| filingDate |
2005-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a32fb5f3c91c754272ba8e06ae245e8 |
| publicationDate |
2006-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006018972-A1 |
| titleOfInvention |
Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs |
| abstract |
The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug wherein the dispersed phase further comprises a non-electrolytic, soluble component having low molecular weight and a diffusion controlling membrane and a dispersion medium substantially free of diffusible counterions, further comprising an excipient capable of associating with water and impeding water activity such that drug dissolution is inhibited prior to administration. The invention also provides methods for preparing such compositions and methods of treatment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8263122-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018273722-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8372415-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010280059-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010278915-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8652492-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010092562-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006134148-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009123539-A1 |
| priorityDate |
2002-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |