| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6a6ef49114ce0e301d4868d4d366948 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-765 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-64 |
| filingDate |
2005-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af21f03d224de36f9325bdfdec16b5e7 |
| publicationDate |
2006-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006018859-A1 |
| titleOfInvention |
Modified human serum albumin with reduced or eliminated affinity to chemical or biological contaminants at Cys 34 |
| abstract |
A modified serum albumin is provided which has been modified at position cysteine 34 of human serum albumin, or at equivalent locations in other mammalian serum albumins, with an amino acid which lacks a sulphydryl group and will thus be less reactive with biological or chemical molecules such as trace metals at this site. Particularly suitable amino acids to substitute for cysteine at position 34 include methionine and other amino acids which are less reactive than cysteine and which maintain the same folding and antigenicity of the native serum albumin. The modified albumin of the present invention is advantageous in that it is binding to trace metals and other contaminants is reduced or eliminated, and it can thus be used more safely and effectively than unmodified albumin with a reduced or eliminated likelihood of causing an allergic reaction in the human being treated with the albumin composition. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633428-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011190902-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9944691-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233228-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10696732-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010268330-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8696759-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10329340-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9493545-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8927694-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9345766-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011059076-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555061-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8475536-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711050-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010092135-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016042554-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3243835-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010268227-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10501524-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10934341-B2 |
| priorityDate |
2004-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |