| abstract |
For purposes of determining the function of a protein, an automated system captures images of cells, each cell located in a predetermined well. After a given cell is exposed to a protein of interest, the system measures the responses of the cell over time, evaluating a variety of cellular parameters. Analytical software within the system evaluates data generated by these measurements, at single-cell resolution. By comparing with various controls the data thus obtained, the system illuminates the function of a protein with respect to one or more disease models, independent of information regarding the structure, chemistry or underlying genomics of the protein. |