http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005288240-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6668c96f41b37b61558847ace34cf230 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21be4eb89b0234d8f727d131bb6a4d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc64567439c37f30f1509dca95a2566a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0052517b21a3f1587b9ded97cfba1d7d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-657181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-657154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-207 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6571 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-207 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7072 |
| filingDate | 2005-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67747dccbca0f8cbe37e054115b003a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c7a6e00e20a3ded8c2ac76aa2f88827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58984fb64827e40003e7269d9b897363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f04a0995c897fba2daf2159065f8888 |
| publicationDate | 2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005288240-A1 |
| titleOfInvention | Novel-prodrugs for phosphorus-containing compounds |
| abstract | Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described: n nwherein: V, W, and W′ are independently selected from the group consisting of —H, alkyl, aralkyl, alicyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, 1-alkenyl, and 1-alkynyl; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group containing 5-7 atoms, optionally 1 heteroatom, substituted with hydroxy, acyloxy, alkoxycarbonyloxy, or aryloxycarbonyloxy attached to a carbon atom that is three atoms from both O groups attached to the phosphorus; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group, optionally containing 1 heteroatom, that is fused to an aryl group at the beta and gamma position to the O attached to the phosphorus; together V and W are connected via an additional 3 carbon atoms to form an optionally substituted cyclic group containing 6 carbon atoms and substituted with one substituent selected from the group consisting of hydroxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, and aryloxycarbonyloxy, attached to one of said carbon atoms that is three atoms from an O attached to the phosphorus; together Z and W are connected via an additional 3-5 atoms to form a cyclic group, optionally containing one heteroatom, and V must be aryl, substituted aryl, heteroaryl, or substituted heteroaryl; together W and W′ are connected via an additional 2-5 atoms to form a cyclic group, optionally containing 0-2 heteroatoms, and V must be aryl, substituted aryl, heteroaryl, or substituted heteroaryl; n Z is selected from the group consisting of —CHR 2 OH, —CHR 2 OC(O)R 3 , —CHR 2 OC(S)R 3 , —CHR 2 OC(S)OR 3 , —CHR 2 OC(O)SR 3 , —CHR 2 OCO 2 R 3 , —OR 2 , —SR 2 , —CHR 2 N 3 , —CH 2 aryl, —CH(aryl)OH, —CH(CH═CR 2 2)OH, —CH(C≡CR 2 )OH, —R 2 , —NR 2 2 , —OCOR 3 , —OCO 2 R 3 , —SCOR 3 , —SCO 2 R 3 , —NHCOR 2 , —NHCO 2 R 3 , —CH 2 NHaryl, —(CH 2 ) p —OR 12 , and —(CH 2 ) p —SR 12 ; p is an integer 2 or 3; with the provisos that: a) V, Z, W, W′ are not all —H; and b) when Z is —R 2 , then at least one of V, W, and W′ is not —H, alkyl, aralkyl, or alicyclic; R 2 is selected from the group consisting of R 3 and —H; R 3 is selected from the group consisting of alkyl, aryl, alicyclic, and aralkyl; R 12 is selected from the group consisting of —H, and lower acyl; M is selected from the group that attached to PO 3 2− , P 2 O 6 3− , or P 3 O 9 4− is a biologically active agent, and is attached to the phosphorus in formula I via a carbon, oxygen, sulfur or nitrogen atom; and pharmaceutically acceptable prodrugs and salts thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004192651-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005282782-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7582758-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7214668-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7193081-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021388-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7498320-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7553826-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7303739-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007203339-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003229225-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7148349-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7151092-B2 |
| priorityDate | 1998-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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