http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005281791-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb5ec9bf8af989434567fb67175cfda7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0657 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05b44540e64e07e2fb33458c0757be9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a93dca4f472be85a0b4d855c78f41cbd |
| publicationDate | 2005-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005281791-A1 |
| titleOfInvention | Method for inducing cardiac myocytes in embryonic stem (ES) cells by induction with precardiac endoderm and mesoderm |
| abstract | A method to induce ES cells to the cardiac phenotype is disclosed whereby avian precardiac endoderm used as feeder/inducer cells induce high percentage conversion of mouse embryonic stem (mES) cells into cardiac myocytes. Upon induction, the majority (˜65%) of co-cultured ES cell-derived embryoid bodies (EBs) become enriched in cardiac myocytes and exhibit rhythmic contractions. When precardiac mesoderm is included with the precardiac endoderm, ˜100% of EBs become rhythmically contractile. The inductive effect of the precardiac endoderm/mesoderm is mimicked by medium conditioned by these cells. Within each EB induced by medium conditioned by precardiac endoderm/mesoderm, over 80% of the cells become cardiac myocytes. The inductive efficacy of medium conditioned by avian precardiac endoderm/mesoderm provides a platform to biochemically define factors that induce cardiac myocyte differentiation in ES cells, and provides a platform for developing other methods for directing the development of particular cells from stem cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008038820-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009055396-A1 |
| priorityDate | 2004-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.