| abstract |
Biodegradable antitumor composition with prolonged release has at least one antitumor agent and a biodegradable oligoester carrier, having a numeric mean relative molecular mass M n of from 650 to 7,500, a mass mean relative molecular mass M w from 800 to 10,000 and a glass transition temperature T g from −35 to 45° C. The carrier is prepared by polycondensation reaction of polyhydric alcohol containing at least 3 hydroxy groups with at least one aliphatic α-hydroxy acid in the molar ratio of polyhydric alcohol to aliphatic α-hydroxy acid of from 0.5:99.5 to 12:88, and is a polyhydric alcohol to the hydroxy groups of which chains created from several molecules of at least one aliphatic α-hydroxy acid are bound by ester bonds. |