| abstract |
Disclosed are methods for the use of neprilysin-encoding polynucleotides in the creation of transformed host cells and transgenic animals. In particular, the use of recombinant adeno-associated viral (rAAV) vector compositions comprising polynucleotide sequences that express one or more biologically-active mammalian neprilysin polypeptides is described. Also disclosed are medicaments and methods for the treatment and amelioration of symptoms of a variety of conditions and neprilysin deficiencies in an animal, including, for example, Alzheimer's disease, and related disorders, as well as neurological and musculoskeletal disorders, including for example, diseases caused by the accumulation of β-amyloid protein in the cells and tissues of affected animals. |