| abstract |
The invention pertains to medical devices, such as stents, having a surface and a first coating layer comprising a first polymer disposed on at least a portion of the surface, in which at least one cavity formed in the first coating layer. A biologically active material is deposited into the cavity, and a second coating layer comprising a second polymer is disposed over the biologically active material in the cavity. The cavity may be formed using an excimer laser or ultrashort laser to ablate the first coating layer, and the biologically active material may be deposited in the cavity using a picoliter dispensing system. Methods for making such medical devices are also disclosed. |