| abstract |
It is intended to provide a method of designing an antiallergic agent, a sleep controlling agent, an antiobestic and a remedy for brain injury acting via the inhibition of the biosynthesis of prostaglandin D 2 . Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis. |