| abstract |
The present invention provides complexes containing an ARTS protein and an IAP protein, compounds that disrupt same, and use of the compounds in treating neuro-degenerative disease, ischemic injury, myelodysplasia, atherosclerosis, various auto-immune diseases, cytopenia, pancreatitis, and periodonitis, and in decreasing susceptibility of a cell to apoptosis. The present invention also provides methods for identifying biologically active regions of ARTS protein, and use of mimetic compounds of same in treating apoptosis-related disorders, cancer, and other neoplastic diseases and disorders. |