| abstract |
A method for preferentially inhibiting release of pro-inflammatory cytokines over release of anti-inflammatory cytokines using a fused pyrazolyl compound of formula (I): n n nA is R or n n nin which R is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is R′, nitro, halogen, —C(O)—OR′, —C(O)—SR′, —C(O)—NR′R″, —(CH 2 ) m OR′, —(CH 2 ) m SR′, —(CH 2 ) m NR′R″, —(CH 2 ) m CN, —(CH 2 ) m C(O)—OR′, —(CH 2 ) m C(O)H, or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R6 together are —O(CH2) n O—, in which each of R′ and R″, independently, is H, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl; and m is 0, 1, 2, 3, 4, 5, or 6; and n is 1, 2, or 3. This invention also covers a method of inhibiting activity of NF-κB with such a compound. |