abstract |
Synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28), comprising a biologically active peptide at least 90% identical to a peptide consisting essentially of the formula: n (a) X 01 ValSerGluIleGlnLeuMetHisAsn (SEQ ID NO:1); LeuGlyLysHisLeuAsnSerMetX 02 Arg ValGluTrpLeuArgLysLysLeu n(b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27; (c) pharmaceutically acceptable salts thereof; or (d) N- or C-derivatives thereof; wherein: n X 01 is Ser, Ala or Gly; and X 02 is Glu or Arg, n nprovided that said peptide is not hPTH(1-26)NH 2 , hPTH(1-27)NH 2 or hPTH(1-28)NH 2 . |